AOPs

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Showing 151 to 175 of 476 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
185 Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova BY-SA None 563: Death/Failure, Colony 1.29
186 unknown MIE leading to renal failure and mortality Cataia Ives BY-SA 1114: Unknown, MIE 351: Increased Mortality 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry BY-SA 1136: Impaired recruitment , Population trajectory Under Development 1.31
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author BY-SA 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova BY-SA 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always BY-SA 1215: TRPA1 activation, TRPA1 Receptor
197 Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova BY-SA 584: Inhibition, sodium channel None 1.29
199 ER mediated breast cancer AOP Cataia Ives BY-SA None None
200 Estrogen receptor activation leading to breast cancer Brendan Ferreri-Hanberry Open for adoption 1181: Activation, Estrogen receptor 1193: N/A, Breast Cancer
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author BY-SA 1205: Activation, Juvenile hormone receptor
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Agnes Aggy BY-SA 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia WPHA/WNT Endorsed 1.53
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1.29
205 AOP from chemical insult to cell death Cataia Ives BY-SA
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry BY-SA 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author BY-SA 1174: Activation, NADPH Oxidase 1277: Reproductive failure
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy BY-SA None 1277: Reproductive failure
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always BY-SA None 1291: Hepatotoxicity
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Evgeniia Kazymova BY-SA None 1277: Reproductive failure