AOP-Wiki

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All Key Events

Showing 1001 to 1025 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1434	Irritation of nasal mucosa inducing sneeze reflex Short Name Irritation induced sneezing	1	Tissue	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1435	Increased neurokinin A (NKA) by neuronal cells Short Name Increased NKA	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1436	neurogenic inflammation of sensory nerves Short Name neurogenic inflammation	0	Cellular	Jun 27, 2017	Jun 27, 2017	None
1437	Sensing of the stressor by pulmonary cells Short Name Sensing of the stressor	0	Molecular	Jun 29, 2017	Jun 29, 2017	None
1438	Transcription of genes encoding acute phase proteins, Increased Short Name	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1439	Systemic acute phase response Short Name Systemic acute phase response	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1440	Formation of HDL-SAA Short Name HDL-SAA formation	0	Cellular	Jun 29, 2017	Jun 29, 2017	None
1441	Increased systemic total cholesterol pool Short Name Systemic cholesterol increased	0	Organ	Jun 29, 2017	Jun 29, 2017	None
1442	Foam cell formation Short Name Foam cell formation	0	Organ	Jun 29, 2017	Jun 29, 2017	None
1443	Atherosclerosis Short Name Atherosclerosis	1	Individual	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1444	Increase, Follicular atresia Short Name Increase, Follicular atresia	0	Organ	Jun 29, 2017	Nov 25, 2020	2 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
1445	Increased, Lipid peroxidation Short Name Increased, LPO	1	Molecular	Jun 29, 2017	Jul 27, 2023	5 AOPs 329: Excessive reactive oxygen species production leading to mortality (3) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 532: CYP450 upregulation leads to Chronic kidney disease
1446	Decrease, Coupling of oxidative phosphorylation Short Name Decrease, Coupling of OXPHOS	3	Molecular	Jun 29, 2017	May 28, 2021	6 AOPs 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
1447	obesity Short Name obesity	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1448	activation of CCAAT/enhancer-binding protein alpha Short Name activation of CEBPA	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1449	increased adipogenesis Short Name increased adipogenesis	0	Tissue	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1450	decreased dopamine Short Name decreased dopamine	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1451	decreased reward Short Name decreased reward	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1452	decreased DNA methylation of tyrosine hydroxylase Short Name	0	Cellular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1453	decreased methylation of dopamine transporter promoter Short Name	0	Cellular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1454	chronic high fat diet Short Name chronic high fat diet	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1455	Incudtion, Sustained inflammatory cytokine release Short Name Sustained inflammatory cytokine release	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1456	Increase, Differentiation of fibroblasts Short Name Differentiation of fibroblasts	0	Cellular	Jul 26, 2017	Jul 26, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1457	Epithelial Mesenchymal Transition Short Name EMT	1	Cellular	Jul 26, 2017	Apr 24, 2024	9 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity
1458	Pulmonary fibrosis Short Name Pulmonary fibrosis	0	Organ	Jul 26, 2017	May 12, 2023	4 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.