AOP-Wiki

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All Key Events

Showing 826 to 850 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1256	increased mantel display Short Name increased mantel display	0	Organ	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1257	Induced parturition Short Name Induced parturition	0	Individual	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1258	Decompartmentalization Short Name Decompartmentalization	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1259	narcosis Short Name narcosis	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1260	Direct mitochondrial inhibition Short Name Direct mitochondrial inhibition	1	Molecular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1262	Apoptosis Short Name Apoptosis	1	Cellular	Feb 7, 2017	Feb 28, 2024	14 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 212: Histone deacetylase inhibition leading to testicular atrophy 285: Inhibition of N-linked glycosylation leads to liver injury 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 502: Decrease, cholesterol synthesis leads to orofacial clefting 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1263	Necrosis Short Name Necrosis	1	Tissue	Feb 7, 2017	Feb 7, 2017	205: AOP from chemical insult to cell death
1264	Increase, Nuclear receptor E75b gene expression Short Name Increase, E75b expression	1	Molecular	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1265	Increase, Fushi tarazu factor-1 gene expression Short Name Increase, Ftz-f1 expression	1	Molecular	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1266	Decrease, Circulating crustacean cardioactive peptide Short Name Decrease, Circulating CCAP	1	Tissue	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1267	Decrease, Ecdysis motoneuron bursts Short Name Decrease, Ecdysis motoneuron bursts	1	Tissue	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1268	Decrease, Excitatory postsynaptic potential Short Name	1	Tissue	Feb 9, 2017	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
1269	Increase, COX-2 expression Short Name Increase, COX-2 expression	1	Molecular	Feb 9, 2017	Mar 20, 2018	21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
1270	Inactivation of PPARγ Short Name Inactivation of PPARγ	0	Molecular	Feb 15, 2017	Dec 26, 2017	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1271	Activation of TGF-β signaling Short Name Activation of TGF-β signaling	0	Cellular	Feb 15, 2017	Feb 15, 2017	206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1272	Differentiation of Myofibroblast Short Name Differentiation of Myofibroblast	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1273	Expression of Collagen Short Name Expression of Collagen	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1274	Production of α-smooth muscle actin Short Name Production of α-smooth muscle actin	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1275	Collagen Deposition Short Name Collagen Deposition	0	Tissue	Feb 15, 2017	Feb 15, 2017	206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1276	Lung fibrosis Short Name Lung fibrosis	0	Organ	Feb 15, 2017	Dec 26, 2017	5 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
1277	Reproductive failure Short Name Reproductive failure	1	Individual	Feb 15, 2017	Feb 15, 2017	3 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1278	ROS formation Short Name ROS formation	1	Molecular	Feb 15, 2017	Sep 16, 2017	2 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Short Name	2	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1280	Activation, HIF-1 Short Name Activation, HIF-1	1	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1281	Increased, DNA Damage-Repair Short Name Increased, DNA Damage-Repair	1	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans