AOP-Wiki

API

All Key Events

Showing 101 to 125 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

234	Activation, PPARα & PPARγ Short Name Activation, PPARα & PPARγ	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
238	Induction, Pre-mature molting Short Name Induction, Pre-mature molting	0		Nov 29, 2016	Nov 29, 2016	None
239	Activation, Pregnane-X receptor, NR1l2 Short Name Activation, Pregnane-X receptor, NR1l2	1	Molecular	Nov 29, 2016	May 22, 2024	2 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
240	Feminisation or incomplete development, Primary and accessory male sex organs Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
243	Reduction, Prostaglandin E2 concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
244	Alkylation, Protein Short Name Alkylation, Protein	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 258: Renal protein alkylation leading to kidney toxicity
245	Activation, PXR/SXR Short Name Activation, PXR/SXR	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 11: Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
246	Increase, RBC congestion in liver Short Name Increase, RBC congestion in liver	2	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
249	Production, Reactive oxygen species Short Name Production, Reactive oxygen species	1	Tissue	Nov 29, 2016	Dec 3, 2016	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
250	Damaging, Red blood cells; hemolysis Short Name Damaging, Red blood cells; hemolysis	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
252	Increase, Renal pathology due to VTG deposition Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	29: Estrogen receptor agonism leading to reproductive dysfunction
253	N/A, Reproductive failure Short Name N/A, Reproductive failure	1	Individual	Nov 29, 2016	Dec 3, 2016	28: Cyclooxygenase inhibition leading reproductive failure
257	Increase, Reactive Oxygen Species production Short Name Increase, ROS production	1	Molecular	Nov 29, 2016	Apr 11, 2021	10 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 330: Excessive reactive oxygen species production leading to mortality (4) 326: Thermal stress leading to population decline (3) 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 488: Increased reactive oxygen species production leading to decreased cognitive function 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
258	Activation, SCD-1 Short Name Activation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
261	Binding, SH-/selen-proteins Short Name Binding, SH-/selen-proteins	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
264	Activation, SREBP-1c Short Name Activation, SREBP-1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
265	Activation, Stellate cells Short Name Activation, Stellate cells	1	Cellular	Nov 29, 2016	Nov 10, 2019	3 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 494: AhR activation leading to liver fibrosis
266	Decrease, Steroidogenic acute regulatory protein (STAR) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
269	Induction, Sustained Cell Proliferation Short Name Induction, Sustained Cell Proliferation	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
270	Induction, Sustained Hepatotoxicity Short Name Induction, Sustained Hepatotoxicity	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
272	Activation/Proliferation, T-cells Short Name Activation/Proliferation, T-cells	2	Organ	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
274	Reduction, Testosterone synthesis by ovarian theca cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
276	Up Regulation, TGFbeta1 expression Short Name Up Regulation, TGFbeta1 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
277	Thyroid hormone synthesis, Decreased Short Name TH synthesis, Decreased	1	Cellular	Nov 29, 2016	Nov 4, 2022	20 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 128: Kidney dysfunction by decreased thyroid hormone 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
279	Thyroperoxidase, Inhibition Short Name Thyroperoxidase, Inhibition	1	Molecular	Nov 29, 2016	Nov 4, 2022	9 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain