AOP-Wiki

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All Key Events

Showing 176 to 200 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

373	Formation, Pro-mutagenic DNA Adducts Short Name Formation, Pro-mutagenic DNA Adducts	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
376	Increased, Induced Mutations in Critical Genes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
377	Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered Hepatic Foci (AHF)) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
378	Tumorigenesis, Hepatocellular carcinoma Short Name Tumorigenesis, Hepatocellular carcinoma	1	Individual	Nov 29, 2016	Nov 29, 2016	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
380	Activation, Pre-MIE: Metabolism of AFB1 Short Name Activation, Pre-MIE: Metabolism of AFB1	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
381	Reduced levels of BDNF Short Name BDNF, Reduced	2	Molecular	Nov 29, 2016	Apr 4, 2019	3 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
382	Aberrant, Dendritic morphology Short Name Aberrant, Dendritic morphology	1	Cellular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
383	Reduced, Presynaptic release of glutamate Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
384	Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
385	Decrease of synaptogenesis Short Name Synaptogenesis, Decreased	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
386	Decrease of neuronal network function Short Name Neuronal network function, Decreased	1	Organ	Nov 29, 2016	May 28, 2018	10 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 501: Excessive iron accumulation leading to neurological disorders 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 522: Estrogen antagonism leading to increased risk of autism-like behavior
387	Binding of agonist, NMDARs Short Name Binding of agonist, NMDARs	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
388	Overactivation, NMDARs Short Name Overactivation, NMDARs	1	Cellular	Nov 29, 2016	Jan 4, 2023	5 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Various neuronal effects induced by elavl3, sox10, and mbp
389	Increased, Intracellular Calcium overload Short Name	1	Cellular	Nov 29, 2016	Jun 26, 2020	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
396	Covalent Binding, Protein Short Name Covalent Binding, Protein	1	Molecular	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
397	Response, Keratinocytes Short Name Response, Keratinocytes	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
398	Activation, Dendritic Cells Short Name Activation, Dendritic Cells	2	Cellular	Nov 29, 2016	Dec 3, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
401	Increase, Biliary excretion TH glucuronide Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	None
402	Cognitive Function, Decreased Short Name Cognitive Function, Decreased	2	Individual	Nov 29, 2016	Aug 9, 2018	13 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 486: Binding to the extracellular protein laminin leading to decreased cognitive function 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
403	Suppression, Immune system Short Name Suppression, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
405	irregularities, ovarian cycle Short Name irregularities, ovarian cycle	1	Individual	Nov 29, 2016	Nov 29, 2016	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
406	impaired, Fertility Short Name impaired, Fertility	1	Individual	Nov 29, 2016	Sep 14, 2023	10 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis 398: Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Short Name	2	Cellular	Nov 29, 2016	May 28, 2021	7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
409	Metabolism of AFB1, Production of Reactive Electrophiles Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
413	Reduction, Testosterone synthesis in Leydig cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	4 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring