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All KERs

Showing 576 to 600 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

842	829: Damage, Lipid bilayer	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
277	250: Damaging, Red blood cells; hemolysis	161: Increase, Liver and splenic hemosiderosis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
278	250: Damaging, Red blood cells; hemolysis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
279	250: Damaging, Red blood cells; hemolysis	246: Increase, RBC congestion in liver	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3108	2200: decline, neural progenitor cells	1978: Microcephaly	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
1265	361: Decline, Population	1210: Alteration, Food-web structures	Nov 29, 2016	Dec 3, 2016	1 AOP 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
3147	1258: Decompartmentalization	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
1787	1545: Decrease in mitochondrial oxidative phosphorylation	1547: Mitochondrial Injury	Dec 19, 2018	Mar 7, 2019	None
1956	1545: Decrease in mitochondrial oxidative phosphorylation	177: Mitochondrial dysfunction	Jun 15, 2019	Jun 15, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1991	1696: Decrease of egg production and cummulative fecundity	679: Decline, Population trajectory	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
2389	1696: Decrease of egg production and cummulative fecundity	997: Decreased, Population size	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
871	851: GABAergic interneurons, Decreased	385: Synaptogenesis, Decreased	Nov 29, 2016	Jan 19, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
359	386: Neuronal network function, Decreased	341: Impairment, Learning and memory	Nov 29, 2016	Jul 15, 2022	6 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2411	386: Neuronal network function, Decreased	402: Cognitive Function, Decreased	Jun 24, 2021	Aug 27, 2021	1 AOP 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
2501	386: Neuronal network function, Decreased	1941: Memory Loss	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2953	386: Neuronal network function, Decreased	2150: Neurological disorder	Jun 21, 2023	Jun 21, 2023	1 AOP 501: Excessive iron accumulation leading to neurological disorders
3123	386: Neuronal network function, Decreased	2209: autism-like behavior	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
656	385: Synaptogenesis, Decreased	188: Neuroinflammation	Nov 29, 2016	Dec 3, 2016	None
443	425: Thyroidal Iodide, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Nov 29, 2016	None
872	425: Thyroidal Iodide, Decreased	277: TH synthesis, Decreased	Nov 29, 2016	Jun 4, 2018	4 AOPs 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
2752	2058: Decrease, 20-hydroxyecdysone	2059: Decrease, knickkopf gene	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1010	993: Decrease, Abdominal muscle contraction	990: Increase, Incomplete ecdysis	Nov 29, 2016	Dec 3, 2016	1 AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
2267	1834: Decrease, ACAD	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
2096	1771: Decrease, ATP pool	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3)

Key Event Relationships (KERs)

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