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Showing 701 to 725 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2551	40: Decrease, Mitochondrial ATP production	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2823	40: Decrease, Mitochondrial ATP production	1532: Decrease, Cardiac contractility	Jan 5, 2023	Jan 5, 2023	1 AOP 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
2094	1770: Decrease, MMP	1477: Decrease, OXPHOS	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2347	1770: Decrease, MMP	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	None
3163	1770: Decrease, MMP	177: Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
2098	1772: Decrease, Neutral lipids	1771: Decrease, ATP pool	Apr 30, 2020	Apr 30, 2020	1 AOP 329: Excessive reactive oxygen species production leading to mortality (3)
2758	2063: Decrease, New cuticle secretion	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
559	572: Decrease, Number of worker bees	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
573	572: Decrease, Number of worker bees	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1470	1366: Decrease, Oogenesis	488: Decrease, Ovulation	Apr 15, 2017	Apr 15, 2017	None
1752	1366: Decrease, Oogenesis	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	6 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 326: Thermal stress leading to population decline (3) 325: Thermal stress leading to population decline (2) 324: Thermal stress leading to population decline (1)
2586	1366: Decrease, Oogenesis	1863: Decrease, Reproduction	Mar 1, 2022	Mar 1, 2022	None
2588	1366: Decrease, Oogenesis	78: Reduction, Cumulative fecundity and spawning	Mar 1, 2022	Mar 1, 2022	4 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2114	1782: Decrease, Oogenesis (F3)	1781: Decrease, Fecundity (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
544	488: Decrease, Ovulation	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Dec 3, 2016	None
687	488: Decrease, Ovulation	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
1471	488: Decrease, Ovulation	330: Decrease, Fertility	Apr 15, 2017	Apr 15, 2017	None
1753	488: Decrease, Ovulation	328: Decrease, Fecundity	Jun 12, 2018	Jun 12, 2018	None
1669	1477: Decrease, OXPHOS	40: Decrease, Mitochondrial ATP production	Oct 10, 2017	Oct 10, 2017	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
1810	1477: Decrease, OXPHOS	1562: Decreased Na/K ATPase activity	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
2095	1477: Decrease, OXPHOS	1771: Decrease, ATP pool	Apr 30, 2020	Apr 30, 2020	1 AOP 328: Excessive reactive oxygen species production leading to mortality (2)
2346	1477: Decrease, OXPHOS	1808: Decrease, ATP synthase activity	Apr 11, 2021	Apr 11, 2021	None
2713	1477: Decrease, OXPHOS	1392: Oxidative Stress	Jul 25, 2022	Jul 25, 2022	None
2726	2041: Decrease, outgrowth	2042: OFC	Jul 28, 2022	May 22, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
1667	1475: Decrease, Photosynthesis	1476: Decrease, Glycolysis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants

Key Event Relationships (KERs)

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