Key Event Relationships (KERs)

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Showing 1426 to 1450 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
461 414: Increase, Luteinizing hormone (LH) 416: Increase proliferation, Leydig cell Nov 29, 2016 Dec 3, 2016
2119 1785: Increase, Mitochondrial ATP synthase antagonism 1477: Decrease, OXPHOS May 8, 2020 May 8, 2020 None
2229 1785: Increase, Mitochondrial ATP synthase antagonism 1771: Decrease, ATP pool Dec 4, 2020 Dec 4, 2020
2189 1813: Increase, Complex I dysfunction 257: Increase, ROS production Nov 2, 2020 Nov 2, 2020 None
1781 1542: Increase, Mitochondrial complex III antagonism 1545: Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
1784 1542: Increase, Mitochondrial complex III antagonism 1546: Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019 None
1872 1542: Increase, Mitochondrial complex III antagonism 1477: Decrease, OXPHOS Mar 19, 2019 Mar 19, 2019 None
1875 1542: Increase, Mitochondrial complex III antagonism 1364: Increase, ROS Mar 19, 2019 Mar 19, 2019 None
2230 1542: Increase, Mitochondrial complex III antagonism 1771: Decrease, ATP pool Dec 4, 2020 Dec 4, 2020
2183 1811: Increase, Complex III dysfunction 1812: Increase, Cyt c release Nov 2, 2020 Nov 2, 2020 None
2186 1811: Increase, Complex III dysfunction 257: Increase, ROS production Nov 2, 2020 Nov 2, 2020 None
2797 2072: Increase, Mitochondrial swelling 55: Cell injury/death Nov 1, 2022 Nov 1, 2022
198 350: Increase, Mortality 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
199 350: Increase, Mortality 361: Decline, Population Nov 29, 2016 Dec 3, 2016 None
1004 350: Increase, Mortality 765: Decreased, population 1 Nov 29, 2016 Dec 3, 2016 None
1013 350: Increase, Mortality 997: Decreased, Population size Nov 29, 2016 Dec 3, 2016 None
2463 350: Increase, Mortality 360: Decrease, Population growth rate Aug 5, 2021 Aug 5, 2021 None
991 962: Increase, Mucin production 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
1315 962: Increase, Mucin production 1251: Chronic, Mucus hypersecretion Nov 29, 2016 Aug 30, 2021 None
2859 962: Increase, Mucin production 1250: Decreased lung function Mar 15, 2023 Mar 16, 2023
1486 1374: Increase, mucosal blood flow 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
1485 1373: Increase, mucous 1380: Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
202 185: Increase, Mutations 336: Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
899 185: Increase, Mutations 885: Increase, Cancer Nov 29, 2016 Dec 3, 2016
1896 185: Increase, Mutations 1182: Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 8, 2019