Key Event Relationships (KERs)

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Showing 126 to 150 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2992 2165: Activation of PPAR 2169: Activation of Angiogenic cytokines Aug 20, 2023 Aug 20, 2023
1720 1507: Activation of PPARγ 149: Increase, Inflammation Mar 18, 2018 Mar 18, 2018 None
1071 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1029: Increased, adipogenesis Nov 29, 2016 Dec 3, 2016
1072 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
1609 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1449: increased adipogenesis Jul 24, 2017 Jul 24, 2017
319 288: Activation of specific nuclear receptors, Transcriptional change 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
1354 1271: Activation of TGF-β signaling 1272: Differentiation of Myofibroblast Feb 15, 2017 Feb 15, 2017 None
1355 1271: Activation of TGF-β signaling 1273: Expression of Collagen Feb 15, 2017 Feb 15, 2017 None
1721 1271: Activation of TGF-β signaling 149: Increase, Inflammation Mar 18, 2018 Mar 18, 2018
1723 1271: Activation of TGF-β signaling 1457: EMT Mar 18, 2018 Mar 18, 2018 None
2600 1974: Activation of TP53 1365: Increase, Apoptosis Mar 9, 2022 Mar 9, 2022 None
2601 1974: Activation of TP53 1560: Altered differentiation Mar 17, 2022 Mar 17, 2022 None
2606 1974: Activation of TP53 1979: Premature differentiation Mar 21, 2022 Mar 21, 2022
3105 1974: Activation of TP53 1262: Apoptosis Jan 10, 2024 Jan 10, 2024
2986 2163: Activation Sema6A 2164: Activation, Dll4-Notch pathway Aug 20, 2023 Aug 20, 2023
1375 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene 1289: Perturbation of cholesterol Feb 15, 2017 Feb 15, 2017
1438 1336: Activation, 5-HT2A 1337: Activate, PLC Apr 14, 2017 Apr 14, 2017
750 9: Activation, 5HT2c 294: N/A, Unknown Nov 29, 2016 Dec 3, 2016
18 18: Activation, AhR 17: Altered expression of AHR/ARNT pathway-dependent genes Nov 29, 2016 Dec 3, 2016 None
19 18: Activation, AhR 80: Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016
473 18: Activation, AhR 451: Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
495 18: Activation, AhR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
496 18: Activation, AhR 465: Increased, FA Influx Nov 29, 2016 Dec 3, 2016 None
499 18: Activation, AhR 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Nov 29, 2016 Dec 3, 2016
506 18: Activation, AhR 466: Up Regulation, LDLR (low density lipoprotein receptor) Nov 29, 2016 Dec 3, 2016