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Showing 151 to 175 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

509	18: Activation, AhR	450: Suppression, VLDL secretion	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
869	18: Activation, AhR	850: Induction, CYP1A2/CYP1A5	Nov 29, 2016	May 7, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
972	18: Activation, AhR	944: dimerization, AHR/ARNT	Nov 29, 2016	Mar 22, 2018	6 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
984	18: Activation, AhR	947: Increase, Early Life Stage Mortality	Nov 29, 2016	Apr 14, 2019	4 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
1656	18: Activation, AhR	462: Up Regulation, SCD-1	Aug 31, 2017	Aug 31, 2017	1 AOP 57: AhR activation leading to hepatic steatosis
1992	18: Activation, AhR	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	None
2568	18: Activation, AhR	149: Increase, Inflammation	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2569	18: Activation, AhR	1262: Apoptosis	Feb 15, 2022	Dec 20, 2022	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2570	18: Activation, AhR	1241: Increased, Motility	Feb 15, 2022	Feb 29, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2571	18: Activation, AhR	1190: Increased, Migration (Endothelial Cells)	Feb 15, 2022	Feb 29, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2572	18: Activation, AhR	1196: Increased, Invasion	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2687	18: Activation, AhR	2021: Increase, slincR expression	Jun 30, 2022	Jun 30, 2022	None
2688	18: Activation, AhR	2020: Decrease, sox9 expression	Jun 30, 2022	Apr 13, 2023	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2689	18: Activation, AhR	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Apr 13, 2023	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2765	18: Activation, AhR	317: Altered, Cardiovascular development/function	Sep 27, 2022	Oct 21, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2883	18: Activation, AhR	295: Induction, Upregulation of glucuronyltransferase activity	Apr 12, 2023	Apr 12, 2023	1 AOP 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2888	18: Activation, AhR	345: N/A, Liver Steatosis	Apr 13, 2023	Apr 13, 2023	None
3219	18: Activation, AhR	459: Increased, Liver Steatosis	May 14, 2024	May 14, 2024	1 AOP 494: AhR activation leading to liver fibrosis
1394	1299: Activation, AKT	1301: Activation, SREBP-1	Apr 12, 2017	Apr 12, 2017	None
1398	1299: Activation, AKT	1300: Activation, mTORC1	Apr 12, 2017	Apr 12, 2017	None
1400	1299: Activation, AKT	1302: Activation, L-FABP	Apr 12, 2017	Apr 12, 2017	None
1661	484: Activation, AKT2	457: Activation, SREBF1	Aug 31, 2017	Aug 31, 2017	1 AOP 62: AKT2 activation leading to hepatic steatosis
787	785: Activation, Androgen receptor	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
2908	785: Activation, Androgen receptor	286: Altered, Transcription of genes by the AR	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2913	785: Activation, Androgen receptor	1183: Decreased, Apoptosis (Epithelial Cells)	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer

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