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Showing 2001 to 2025 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2917	1599: Inflammatory events	2136: prostatic intraepithelial neoplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
2978	2158: IAV binds receptor	2159: IAV cell entry	Aug 11, 2023	Jan 18, 2024	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3055	2193: IAV budding	2194: infection proliferation	Oct 3, 2023	Oct 3, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3030	2159: IAV cell entry	2180: immune mechanisms antagonized	Aug 23, 2023	Aug 23, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
3053	2192: IAV production increased	2193: IAV budding	Oct 3, 2023	Oct 3, 2023	1 AOP 506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
1520	1316: Inhibit, serotonin transporter activity	1317: Decreased, serotonin transporter activity	May 30, 2017	May 30, 2017	None
2707	2039: Inhibition, GABAAr	1527: Increase, Cell membrane depolarization	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2162	1799: Inhibition of 11β-HSD	1756: Decreased, 11KT	Jul 13, 2020	Jul 13, 2020	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2401	1880: ALDH1A (RALDH), inhibition	1881: Decreased, atRA concentration	May 24, 2021	Nov 11, 2021	2 AOPs 398: Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1952	1660: betaine-homocysteine methyltransferase inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
2694	2023: Inhibition CerS	2024: Reduced complex sphingolipids	Jul 19, 2022	Jul 20, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
2697	2023: Inhibition CerS	2033: Increased S1-P	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
1949	1657: CBS inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
3245	2235: Inhibition of E4 (Uracil-DNA Glycosylase)	1497: Recruitment of inflammatory cells	Jun 10, 2024	Jun 10, 2024	1 AOP 533: C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
2402	1884: Inhibition of Fyna	1885: Inhibition of Plxna2	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
2539	1960: Inhibition of Ikr	1961: Prolongation of Action Potential	Dec 13, 2021	Dec 13, 2021	None
2024	1715: Inhibition of JAK3	1716: STAT5 inhibition	Jan 5, 2020	Nov 3, 2021	1 AOP 315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1969	1672: Inhibition of LS function.	1673: Alveolar collapse	Jul 3, 2019	Jul 3, 2019	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
2255	1672: Inhibition of LS function.	1498: Loss of alveolar capillary membrane integrity	Jan 8, 2021	Jan 8, 2021	None
2256	1672: Inhibition of LS function.	1677: Reduced tidal volume	Jan 8, 2021	Jan 8, 2021	None
2370	1672: Inhibition of LS function.	1250: Decreased lung function	Apr 27, 2021	Apr 27, 2021	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
1637	1463: Inhibition of lysyl oxidase	1464: Reduction of collagen crosslinking	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1951	1658: Methionine synthase	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1950	1659: MTHFR inhibition	1661: Homocysteine increases	Jun 14, 2019	Jun 14, 2019	None
1673	1481: Inhibition, mitochondrial DNA polymerase gamma (Pol gamma)	1482: Depletion, mtDNA	Oct 25, 2017	Oct 25, 2017	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity

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