Prototypical Stressors

Showing 576 to 600 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

770	Polyvinyl chloride	Polyvinyl chloride, CAS-RN: 9002-86-2, DTXSID5025940	505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
242	Ponasterone A	Ponasterone A, CAS-RN: 13408-56-5, DTXSID0040595	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
522	Porcupine		298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
455	Potassium bromate	Potassium bromate, CAS-RN: 7758-01-2, DTXSID6020195	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
772	PPAR agonist		529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
608	Pralnacasan (VX-740)		None
487	Pralnacasan (VX-740) and Belnacasan (VX-765)		None
764	Preferred: Altered Gravity		None
702	Probucol	Probucol, CAS-RN: 23288-49-5, DTXSID2045440	None
705	Procainamide	Procainamide, CAS-RN: 51-06-9, DTXSID7023512	None
47	Prochloraz	Prochloraz, CAS-RN: 67747-09-5, DTXSID4024270	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
565	Procymidone	Procymidone, CAS-RN: 32809-16-8, DTXSID9033923	None
505	Progesterone,estrogen,melatonin,Letrozole		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
287	Propiconazole	Propiconazole, CAS-RN: 60207-90-1, DTXSID8024280	None
155	Propyl Acetate	Propyl acetate, CAS-RN: 109-60-4, DTXSID6021901	None
139	Propylene oxide		None
582	Propylpyrazoletriol		None
48	Propylthiouracil	6-Propyl-2-thiouracil, CAS-RN: 51-52-5, DTXSID5021209	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
681	Prototypical stressor		211: Handbook development AOP
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
541	psychosocial stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
171	Pyrethrins and Pyrethroids		2 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
419	Pyridaben	Pyridaben, CAS-RN: 96489-71-3, DTXSID5032573	None