AOP-Wiki

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All Key Events

Showing 1101 to 1125 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1535	Heart failure Short Name Heart failure	0	Organ	Jun 19, 2018	Jun 19, 2018	4 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1536	Disruption, Intracellular calcium mobilization Short Name	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1537	Disruption, Sarcomere assembly Short Name Disruption, Sarcomere assembly	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1538	Decreased protection against oxidative stress Short Name	0	Cellular	Sep 13, 2018	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1539	Endocytotic lysosomal uptake Short Name Endocytosis	1	Molecular	Nov 6, 2018	Apr 17, 2024	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1540	lysosomal disruption EMPTY Short Name lysosomal EMPTY	0	Molecular	Nov 12, 2018	Apr 17, 2024	None
1541	Mitochondrial Complex I inhibition Short Name Mitochondrial Complex I inhibition	0	Molecular	Dec 19, 2018	Dec 19, 2018	None
1542	Increase, Mitochondrial complex III antagonism Short Name	0	Molecular	Dec 19, 2018	Dec 4, 2020	3 AOPs 273: Mitochondrial complex inhibition leading to liver injury 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2)
1543	Mitochondrial Complex IV inhibition Short Name Mitochondrial Complex IV inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1544	Mitochondrial Complex V inhibition Short Name Mitochondrial Complex V inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1545	Decrease in mitochondrial oxidative phosphorylation Short Name	0	Cellular	Dec 19, 2018	Dec 19, 2018	273: Mitochondrial complex inhibition leading to liver injury
1546	Increased reactive oxygen species (in the mitochondria) Short Name	0	Cellular	Dec 19, 2018	Dec 19, 2018	273: Mitochondrial complex inhibition leading to liver injury
1547	Mitochondrial Injury Short Name Mitochondrial Injury	0	Cellular	Dec 19, 2018	Dec 19, 2018	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1548	Necrotic Tissue Short Name Necrotic Tissue	0	Tissue	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1549	Liver Injury Short Name Liver Injury	0	Organ	Dec 19, 2018	Mar 7, 2019	3 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury 285: Inhibition of N-linked glycosylation leads to liver injury
1550	Deposition of Ionizing Energy Short Name Ionizing Energy	0	Molecular	Dec 19, 2018	Dec 13, 2021	396: Deposition of ionizing energy leads to population decline via impaired meiosis
1552	Inadequate DNA repair (deprecated, please use https://aopwiki.org/events/155) Short Name DNA repair	0	Molecular	Dec 19, 2018	Jan 25, 2019	None
1553	Increase mutations Short Name Increase mutations	0	Molecular	Dec 19, 2018	Dec 19, 2018	None
1554	Increase Chromosomal Aberrations Short Name Increase chromosomal aberrations	0	Molecular	Dec 19, 2018	Aug 27, 2023	443: DNA damage and mutations leading to Metastatic Breast Cancer
1555	Increase cell proliferation Short Name Increase cell proliferation	0	Cellular	Dec 19, 2018	Dec 19, 2018	393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1556	Increase, lung cancer Short Name Increase, lung cancer	0	Organ	Dec 19, 2018	Jan 10, 2023	272: Deposition of energy leading to lung cancer
1557	Neural crest cell migration, reduced Short Name Reduced neural crest cell migration	0	Cellular	Dec 20, 2018	Dec 20, 2018	2 AOPs 274: Histone deacetylase inhibition leads to impeded craniofacial development 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1558	Collagen production, reduced Short Name Reduced collagen production	0	Tissue	Dec 20, 2018	Dec 20, 2018	274: Histone deacetylase inhibition leads to impeded craniofacial development
1559	Facial cartilage structures are reduced in size and morphologically distorted Short Name	0	Tissue	Dec 20, 2018	Dec 20, 2018	2 AOPs 274: Histone deacetylase inhibition leads to impeded craniofacial development 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
1560	Altered differentiation Short Name Altered differentiation	0	Cellular	Dec 20, 2018	Mar 17, 2022	275: Histone deacetylase inhibition leads to neural tube defects