AOP-Wiki

API

All KERs

Showing 451 to 475 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2577	1262: Apoptosis	1971: tumor growth	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2675	1262: Apoptosis	2011: Emphysema	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2792	1262: Apoptosis	2041: Decrease, outgrowth	Oct 27, 2022	Apr 11, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2967	1262: Apoptosis	352: N/A, Neurodegeneration	Jul 18, 2023	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3106	1262: Apoptosis	2200: decline, neural progenitor cells	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2198	1817: Apoptotic cell death	1633: Increase in inflammation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
2192	1814: Reactive Metabolite	1816: Mitochondrial dysfunction EMPTY	Nov 2, 2020	Nov 2, 2020	None
2194	1814: Reactive Metabolite	1818: Immune cell activation	Nov 2, 2020	Nov 2, 2020	1 AOP 362: Immune mediated hepatitis
3151	1814: Reactive Metabolite	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 362: Immune mediated hepatitis
3199	1755: beta-catenin activation	1457: EMT	Apr 23, 2024	Apr 23, 2024	1 AOP 298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
248	214: Bile accumulation, Pathological condition	288: Activation of specific nuclear receptors, Transcriptional change	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
928	214: Bile accumulation, Pathological condition	87: Release, Cytokine	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
930	214: Bile accumulation, Pathological condition	249: Production, Reactive oxygen species	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
877	857: Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain	858: Decreased, PPARalpha transactivation of gene expression	Nov 29, 2016	Nov 29, 2016	None
666	667: Binding at picrotoxin site, iGABAR chloride channel	64: Reduction, Ionotropic GABA receptor chloride channel conductance	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
3183	2218: Binding of (ant)agonist to liver X receptor	2221: LXR activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3187	2218: Binding of (ant)agonist to liver X receptor	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3184	2219: Binding of (ant)agonist to PPAR alpha	2216: Binding of antagonist to thyroid hormone receptor	Apr 12, 2024	Apr 12, 2024	None
3185	2219: Binding of (ant)agonist to PPAR alpha	2222: PPAR alpha activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3188	2219: Binding of (ant)agonist to PPAR alpha	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3195	2219: Binding of (ant)agonist to PPAR alpha	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2304	1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	257: Increase, ROS production	Mar 30, 2021	Mar 30, 2021	None
2319	1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1115: Increased, Reactive oxygen species	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
919	875: Binding of agonist, Ionotropic glutamate receptors	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None

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