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All KERs

Showing 51 to 75 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

662	570: Accumulation, Damaged mitochondrial DNA	571: Accelerated, Aging	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
472	327: Accumulation, Fatty acid	291: Accumulation, Triglyceride	Nov 29, 2016	Dec 3, 2016	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
514	327: Accumulation, Fatty acid	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
515	327: Accumulation, Fatty acid	459: Increased, Liver Steatosis	Nov 29, 2016	Dec 3, 2016	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis
866	846: Accumulation, Highly carboxylated porphyrins	369: Uroporphyria	Nov 29, 2016	May 7, 2018	1 AOP 131: Aryl hydrocarbon receptor activation leading to uroporphyria
2265	291: Accumulation, Triglyceride	459: Increased, Liver Steatosis	Jan 15, 2021	Mar 27, 2024	5 AOPs 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis 57: AhR activation leading to hepatic steatosis
3162	291: Accumulation, Triglyceride	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 34: LXR activation leading to hepatic steatosis
2524	1938: ACE2 increased shedding	1935: Ang (1-7) levels reduced	Oct 28, 2021	Oct 28, 2021	None
454	10: ACh Synaptic Accumulation	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Nov 29, 2016	None
456	10: ACh Synaptic Accumulation	39: Increased Cholinergic Signaling	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
459	10: ACh Synaptic Accumulation	12: AchE Inhibition	Nov 29, 2016	Dec 3, 2016	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1857	10: ACh Synaptic Accumulation	1602: Activation, Muscarinic Acetylcholine Receptors	Feb 13, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
11	12: AchE Inhibition	10: ACh Synaptic Accumulation	Nov 29, 2016	Sep 10, 2023	4 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
449	12: AchE Inhibition	444: Increased, Atrioventricular block and bradycardia	Nov 29, 2016	Dec 3, 2016	None
450	12: AchE Inhibition	445: Respiratory distress/arrest	Nov 29, 2016	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
451	12: AchE Inhibition	39: Increased Cholinergic Signaling	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
452	12: AchE Inhibition	351: Increased Mortality	Nov 29, 2016	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
453	12: AchE Inhibition	442: Decreased, Population trajectory	Nov 29, 2016	Dec 20, 2019	None
2007	12: AchE Inhibition	1703: Cardiovascular dysregulation	Nov 25, 2019	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2014	12: AchE Inhibition	1705: Impaired coordination and movement	Dec 20, 2019	Dec 20, 2019	1 AOP 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
2016	12: AchE Inhibition	360: Decrease, Population growth rate	Dec 20, 2019	Dec 20, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
2653	12: AchE Inhibition	1391: Activation of Cyp2E1	May 16, 2022	May 16, 2022	1 AOP 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
3063	12: AchE Inhibition	2195: Increase, CNS Neural cell death	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3064	12: AchE Inhibition	1944: Dysfunctional synapses	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2032	1724: Acinar cell proliferation	1725: Acinar cell tumors	Jan 8, 2020	Jan 8, 2020	1 AOP 316: Trypsin inhibition leading to pancreatic acinar cell tumors

Key Event Relationships (KERs)

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