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All KERs

Showing 976 to 1000 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1996	944: dimerization, AHR/ARNT	1697: Increase, DNMT expression	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
2682	944: dimerization, AHR/ARNT	2020: Decrease, sox9 expression	Jun 30, 2022	Jun 30, 2022	None
2683	944: dimerization, AHR/ARNT	2021: Increase, slincR expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2359	1869: Diminished Protective Response to ROS	1845: Coagulation	Apr 20, 2021	Jan 26, 2024	1 AOP 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
2413	1869: Diminished Protective Response to ROS	1895: inflammasome activity, increased	Jun 25, 2021	Jun 25, 2021	1 AOP 406: SARS-CoV-2 infection leading to hyperinflammation
2537	1958: Direct hERG channel blockage	1960: Inhibition of Ikr	Dec 13, 2021	Dec 13, 2021	None
3145	1260: Direct mitochondrial inhibition	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
737	721: Disorganization, Meiotic Spindle	752: Altered, Meiotic chromosome dynamics	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2249	1830: Displacement, Serum thyroxine (T4) from carrier protein	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2246	958: Displacement, Serum thyroxine (T4) from transthyretin	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
3249	2238: Disrupted calcium-dependent signalling pathway	2239: Increased, disregulation of smooth muscle cells	Jun 19, 2024	Jun 19, 2024	None
3252	2238: Disrupted calcium-dependent signalling pathway	2237: Increased, Endothelin protein	Jun 19, 2024	Jun 19, 2024	None
3210	2225: Disrupted Lipid Storage	327: Accumulation, Fatty acid	May 8, 2024	May 8, 2024	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
3211	2225: Disrupted Lipid Storage	291: Accumulation, Triglyceride	May 8, 2024	May 8, 2024	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
2481	1882: Oocyte meiosis, disrupted	1883: Ovarian follicle pool, reduced	Sep 13, 2021	Nov 11, 2021	1 AOP 398: Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
3221	2227: Disrupted PPAR isoform nuclear signaling	2224: Dysregulation of transcriptional expression within PPAR signaling network	May 14, 2024	May 23, 2024	1 AOP 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
3222	2227: Disrupted PPAR isoform nuclear signaling	179: Decreased, Mitochondrial fatty acid beta-oxidation	May 14, 2024	May 14, 2024	None
2615	1977: Altered kinetics of sodium channel	698: Altered, Action Potential	Mar 25, 2022	Mar 25, 2022	None
2625	1977: Altered kinetics of sodium channel	1983: Disruption in action potential generation	Mar 31, 2022	Mar 31, 2022	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
1761	1536: Disruption, Intracellular calcium mobilization	1537: Disruption, Sarcomere assembly	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
911	898: Disruption, Lysosome	257: Increase, ROS production	Nov 29, 2016	Dec 3, 2016	None
921	898: Disruption, Lysosome	209: Peptide Oxidation	Nov 29, 2016	Nov 29, 2016	None
993	898: Disruption, Lysosome	177: Mitochondrial dysfunction	Nov 29, 2016	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1679	898: Disruption, Lysosome	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
715	720: Disruption, Microtubule dynamics	721: Disorganization, Meiotic Spindle	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring

Key Event Relationships (KERs)

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