Prototypical Stressors

Showing 376 to 400 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

678	Impregnation products		None
272	Increase cortisone levels (induced by stress)		3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation
158	Indole	Indole, CAS-RN: 120-72-9, DTXSID0020737	None
27	Indomethacin	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid, CAS-RN: 53-86-1, DTXSID9020740	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
699	Influenza Virus		506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
613	inguratimod		None
246	Inokosterone	Inokosterone, CAS-RN: 15130-85-5, DTXSID40164756	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
377	Insoluble nano-sized particles		237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
508	Interleukin-6	Interleukin-6, CAS-RN: 308067-66-5, DTXSID6041050	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
269	Iodine deficiency		None
451	Ionizing Radiation		18 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 470: Deposition of energy leads to vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts
212	iopanoic acid	Iopanoic acid, CAS-RN: 96-83-3, DTXSID6023159	155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
617	IRAK4 inhibitors		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
232	Iron compounds		None
750	Iron nanoparticles		392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
662	Irradiation		None
258	Isoflavones		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
352	Isoflurane	Isoflurane, CAS-RN: 26675-46-7, DTXSID3020752	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
358	Isoniazid	Isoniazid, CAS-RN: 54-85-3, DTXSID8020755	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
28	Isopropyl methanesulfonate	Isopropyl methanesulfonate, CAS-RN: 926-06-7, DTXSID8031497	None
690	Itraconazole	Itraconazole, CAS-RN: 84625-61-6, DTXSID3023180	None
531	Kaempferol	Kaempferol, CAS-RN: 520-18-3, DTXSID7020768	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
29	Kainic acid	Kainic acid, CAS-RN: 487-79-6, DTXSID7040526	None
397	KCN	Potassium cyanide, CAS-RN: 151-50-8, DTXSID0024268	None
475	Kenpaullone		None