Prototypical Stressors

Showing 326 to 350 of 777 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

659	Formaldehyde	Formaldehyde, CAS-RN: 50-00-0, DTXSID7020637	None
174	Fulvestrant	Fulvestrant, CAS-RN: 129453-61-8, DTXSID4022369	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
745	Fumonisin B1	Fumonisin B1, CAS-RN: 116355-83-0, DTXSID6020644	449: Ceramide synthase inhibition leading to neural tube defects
626	fungi		None
552	furan	Furan, CAS-RN: 110-00-9, DTXSID6020646	None
157	Gabapentin	Gabapentin, CAS-RN: 60142-96-3, DTXSID0020074	None
273	Gamma radiation		8 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 396: Deposition of ionizing energy leads to population decline via impaired meiosis
757	GANT 58		491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
756	GANT61	GANT61, CAS-RN: 500579-04-4, DTXSID50329591	491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
710	Geldanamycin	Geldanamycin, CAS-RN: 30562-34-6, DTXSID7042691	None
208	Gemfibrozil	Gemfibrozil, CAS-RN: 25812-30-0, DTXSID0020652	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
76	Genistein	Genistein, CAS-RN: 446-72-0, DTXSID5022308	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
328	Gentamicin	Gentamicin, CAS-RN: 1403-66-3, DTXSID5034642	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
517	Gevokizumab		None
373	Glibenclamide		343: S-adenosylmethionine depletion leading to population decline (2)
506	glucocorticoids		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
578	Glycyrrhizin	Glycyrrhizin, CAS-RN: 1405-86-3, DTXSID8047006	348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
724	Gold	Gold, CAS-RN: 7440-57-5, DTXSID3064697	None
712	Gold nanoparticles		None
482	GOLPH3		None
530	Gossypol	Gossypol, CAS-RN: 303-45-7, DTXSID5023110	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
255	Graphene oxide nanoparticles		2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
151	GW6471		6: Antagonist binding to PPARα leading to body-weight loss
239	Halofenozide	Halofenozide, CAS-RN: 112226-61-6, DTXSID4032619	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
160	Halogenated phenols		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity