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All Key Events

Showing 1301 to 1325 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1754	Porcupine-induced Wnt secretion and Wnt signaling activation Short Name	1	Cellular	Mar 23, 2020	Nov 25, 2022	298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
1755	beta-catenin activation Short Name beta-catenin activation	1	Cellular	Mar 23, 2020	Nov 25, 2022	298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
1756	Decreased, plasma 11-ketotestosterone level Short Name Decreased, 11KT	1	Tissue	Mar 23, 2020	May 24, 2022	3 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1757	Reduce, Sperm count Short Name Reduce, Sperm count	0	Individual	Apr 6, 2020	Apr 6, 2020	2 AOPs 322: Alkylation of DNA leading to reduced sperm count 400: Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
1758	Impaired, Spermatogenesis Short Name Impaired, Spermatogenesis	1	Organ	Apr 16, 2020	Apr 10, 2024	4 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 521: Essential element imbalance leads to reproductive failure via oxidative stress 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
1759	Increase, Cripto-1 expression Short Name Increase, Cripto-1 expression	1	Cellular	Apr 20, 2020	Jul 10, 2020	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1760	Inhibition, Activin signaling Short Name Inhibition, Activin signaling	1	Cellular	Apr 21, 2020	Jul 10, 2020	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1761	Inhibition, Fin regeneration Short Name Inhibition, Fin regeneration	1	Tissue	Apr 21, 2020	Jul 10, 2020	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1762	Urothelial cell injury/death Short Name cell injury	0	Cellular	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1763	Urothelial Tumor Short Name carcinogenicity	0	Organ	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1765	Increase, Formation of DNA photoproducts Short Name	0	Molecular	Apr 30, 2020	Apr 30, 2020	331: Formation of DNA photoproducts leading to growth inhibition (1)
1767	Increase, Protein oxidation Short Name Increase, Protein oxidation	0	Molecular	Apr 30, 2020	Apr 30, 2020	327: Excessive reactive oxygen species production leading to mortality (1)
1768	Increase, Abnormal osmoregulation Short Name Increase, Abnormal osmoregulation	0	Tissue	Apr 30, 2020	Nov 2, 2020	327: Excessive reactive oxygen species production leading to mortality (1)
1769	Increase, Body fluid overload Short Name Increase, Body fluid overload	0	Tissue	Apr 30, 2020	Apr 30, 2020	327: Excessive reactive oxygen species production leading to mortality (1)
1770	Decrease, Mitochondrial membrane potential Short Name Decrease, MMP	0	Cellular	Apr 30, 2020	Apr 30, 2020	3 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1771	Decrease, Adenosine triphosphate pool Short Name Decrease, ATP pool	1	Cellular	Apr 30, 2020	Jun 14, 2021	10 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 324: Thermal stress leading to population decline (1) 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
1772	Decrease, Neutral lipids Short Name Decrease, Neutral lipids	0	Tissue	Apr 30, 2020	Apr 30, 2020	329: Excessive reactive oxygen species production leading to mortality (3)
1773	Decrease, Global DNA methylation Short Name Decrease, Global DNA methylation	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1774	Increase, Caspase transcription Short Name Increase, Casp transcription	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4)
1775	Increase, Oocyte apoptosis Short Name Increase, Oocyte apoptosis	0	Cellular	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 396: Deposition of ionizing energy leads to population decline via impaired meiosis 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
1776	Increase, Ovarian somatic cell apoptosis Short Name	0	Cellular	Apr 30, 2020	Apr 30, 2020	2 AOPs 337: DNA methyltransferase inhibition leading to population decline (2) 339: DNA methyltransferase inhibition leading to population decline (4)
1777	Increase, Ovarian follicle breakdown Short Name Increase, Ovarian follicle breakdown	0	Organ	Apr 30, 2020	Apr 30, 2020	2 AOPs 337: DNA methyltransferase inhibition leading to population decline (2) 339: DNA methyltransferase inhibition leading to population decline (4)
1778	Decrease, Heritable DNA methylation (F3) Short Name	0	Molecular	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1779	Increase, Caspase transcription (F3) Short Name Increase, Casp transcription (F3)	0	Molecular	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1780	Increase, Oocyte apoptosis (F3) Short Name Increase, Oocyte apoptosis (F3)	0	Cellular	Apr 30, 2020	Apr 30, 2020	340: DNA methyltransferase inhibition leading to transgenerational effects (1)