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Showing 1301 to 1325 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3056	2195: Increase, CNS Neural cell death	2196: Decrease, elavl3	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3057	2195: Increase, CNS Neural cell death	2197: Decrease, sox10	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3058	2195: Increase, CNS Neural cell death	2198: Decrease, mbp	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1450	1334: Increase, cortisone	122: Activation, Glucocorticoid Receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
1351	1269: Increase, COX-2 expression	317: Altered, Cardiovascular development/function	Feb 9, 2017	Mar 28, 2018	1 AOP 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
2078	1759: Increase, Cripto-1 expression	1760: Inhibition, Activin signaling	Apr 21, 2020	Jul 7, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2082	1759: Increase, Cripto-1 expression	1761: Inhibition, Fin regeneration	Apr 21, 2020	Jul 10, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2184	1812: Increase, Cyt c release	1365: Increase, Apoptosis	Nov 2, 2020	Nov 2, 2020	None
3050	1812: Increase, Cyt c release	2188: Caspase activation	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2764	2064: Increase, Cytosolic Ca	1825: Increase, Cell death	Sep 13, 2022	Sep 13, 2022	None
2766	2064: Increase, Cytosolic Ca	55: Cell injury/death	Sep 27, 2022	Sep 27, 2022	1 AOP 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
1693	1305: Increase, cytosolic fatty acid	1489: steatohepatitis	Nov 13, 2017	Nov 13, 2017	None
1694	1305: Increase, cytosolic fatty acid	459: Increased, Liver Steatosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
766	768: Increase, Cytotoxicity	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
887	768: Increase, Cytotoxicity	868: Increase, Tissue Degeneration, Necrosis & Atrophy	Nov 29, 2016	Nov 29, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
767	770: Increase, Cytotoxicity (club cells)	733: Increase, Necrosis (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
777	776: Increase, Cytotoxicity (corneal cells)	777: Increase, Inflammation (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
780	780: Increase, Cytotoxicity (epithelial cells)	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
2659	780: Increase, Cytotoxicity (epithelial cells)	1115: Increased, Reactive oxygen species	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2664	780: Increase, Cytotoxicity (epithelial cells)	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
788	786: Increase, Cytotoxicity (hepatocytes)	787: Increase, Regenerative cell proliferation (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
708	709: Increase, Cytotoxicity (renal tubular cell)	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
1676	709: Increase, Cytotoxicity (renal tubular cell)	814: Occurrence, Kidney toxicity	Oct 25, 2017	Mar 8, 2022	4 AOPs 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
784	783: Increase, Cytotoxicity (tubular epithelial cells)	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
796	794: Increase, Cytotoxicity (urothelial cells)	795: Increase, Regenerative cell proliferation (urothelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)

Key Event Relationships (KERs)

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