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All KERs

Showing 1851 to 1875 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1463	1357: Increased, RDX dose	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1555	1357: Increased, RDX dose	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
1162	1115: Increased, Reactive oxygen species	1088: Increased, Oxidative Stress	Nov 29, 2016	Jul 31, 2023	3 AOPs 186: unknown MIE leading to renal failure and mortality 396: Deposition of ionizing energy leads to population decline via impaired meiosis 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
1696	1115: Increased, Reactive oxygen species	1491: increased, oncotic necrosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1965	1115: Increased, Reactive oxygen species	1669: Increased, DNA damage and mutation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2009	1115: Increased, Reactive oxygen species	1392: Oxidative Stress	Dec 3, 2019	Apr 11, 2024	2 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress
2033	1115: Increased, Reactive oxygen species	1648: β-catenin activation	Jan 19, 2020	Jan 19, 2020	None
2320	1115: Increased, Reactive oxygen species	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
2324	1115: Increased, Reactive oxygen species	1501: Increased extracellular matrix deposition	Apr 10, 2021	Apr 10, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
2328	1115: Increased, Reactive oxygen species	1855: Increased Sodium-sensitive hypertension	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2460	1115: Increased, Reactive oxygen species	1445: Increased, LPO	Aug 5, 2021	Apr 11, 2024	3 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress
2549	1115: Increased, Reactive oxygen species	1861: D1 protein deactivation	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
2550	1115: Increased, Reactive oxygen species	1770: Decrease, MMP	Jan 21, 2022	Jan 21, 2022	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2594	1115: Increased, Reactive oxygen species	68: Accumulation, Collagen	Mar 3, 2022	Mar 3, 2022	None
2660	1115: Increased, Reactive oxygen species	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2966	1115: Increased, Reactive oxygen species	1262: Apoptosis	Jul 18, 2023	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3092	1115: Increased, Reactive oxygen species	233: Decreased, PPAR-gamma activation	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1704	1497: Recruitment of inflammatory cells	1498: Loss of alveolar capillary membrane integrity	Jan 5, 2018	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1964	1497: Recruitment of inflammatory cells	1115: Increased, Reactive oxygen species	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2354	1497: Recruitment of inflammatory cells	1868: Hyperinflammation	Apr 20, 2021	Feb 8, 2023	2 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2491	1497: Recruitment of inflammatory cells	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2492	1497: Recruitment of inflammatory cells	1932: GI disorders	Oct 19, 2021	Oct 19, 2021	None
2543	1497: Recruitment of inflammatory cells	1954: Gut dysbiosis	Dec 15, 2021	Dec 15, 2021	None
2658	1497: Recruitment of inflammatory cells	780: Increase, Cytotoxicity (epithelial cells)	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2761	1497: Recruitment of inflammatory cells	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)

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