AOP-Wiki

API

All KERs

Showing 2676 to 2700 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2580	1046: Suppression, Estrogen receptor (ER) activity	1047: Increased, secretion of GnRH from hypothalamus	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1255	1202: Suppression, IL-2 and IL-4 production	979: Interference, nuclear localization of NFAT	Nov 29, 2016	Dec 3, 2016	None
1510	1202: Suppression, IL-2 and IL-4 production	984: Impairment, T-cell dependent antibody response	May 19, 2017	Jun 27, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
570	403: Suppression, Immune system	576: Increased, Viral susceptibility	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
388	152: Suppression, Inflammatory cytokines	168: Decreased, Lymphocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1258	1203: Suppression, Suppression of production of cytotoxic T-cells	984: Impairment, T-cell dependent antibody response	Nov 29, 2016	Dec 3, 2016	None
1260	1203: Suppression, Suppression of production of cytotoxic T-cells	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1259	1204: Suppression, Suppression of T-cell dependent antibody production	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1823	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	986: Impairment of TDAR	Dec 25, 2018	Dec 25, 2018	None
3216	450: Suppression, VLDL secretion	459: Increased, Liver Steatosis	May 9, 2024	May 9, 2024	1 AOP 57: AhR activation leading to hepatic steatosis
2362	1870: Sustentacular cells, decrease	1871: olfacotry neurons, decrease	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2365	1870: Sustentacular cells, decrease	1873: anosmia	Apr 26, 2021	Apr 26, 2021	1 AOP 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
2504	1944: Dysfunctional synapses	386: Neuronal network function, Decreased	Oct 26, 2021	Oct 26, 2021	2 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2808	1944: Dysfunctional synapses	341: Impairment, Learning and memory	Dec 11, 2022	Dec 11, 2022	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3065	1944: Dysfunctional synapses	1582: Impaired axonial transport	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3078	1944: Dysfunctional synapses	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
110	89: Synthesis, De Novo Fatty Acid (FA)	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
1590	1439: Systemic acute phase response	1440: HDL-SAA formation	Jun 29, 2017	Jun 29, 2017	None
2860	1439: Systemic acute phase response	1443: Atherosclerosis	Mar 28, 2023	Dec 18, 2023	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
541	486: inflammation	484: Activation, AKT2	Nov 29, 2016	Dec 3, 2016	1 AOP 62: AKT2 activation leading to hepatic steatosis
2034	1704: test	1114: Unknown, MIE	Jan 26, 2020	Jan 26, 2020	None
2037	1704: test	294: N/A, Unknown	Jan 26, 2020	Jan 26, 2020	None
2019	1708: Th17 cell migration and inflammation induction	1709: Skin disease	Dec 27, 2019	Dec 27, 2019	1 AOP 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1636	1462: Thiol protein adducts	1463: Inhibition of lysyl oxidase	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
305	277: TH synthesis, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Oct 10, 2022	18 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 128: Kidney dysfunction by decreased thyroid hormone 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals

Key Event Relationships (KERs)

All KERs