AOP-Wiki

API

All KERs

Showing 376 to 400 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3194	2221: LXR activity, altered	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2773	2066: Altered Signaling	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
2775	2066: Altered Signaling	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
2840	2066: Altered Signaling	2098: Abnormal Neural Remodeling	Jan 25, 2023	Mar 21, 2023	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2843	2066: Altered Signaling	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Mar 22, 2023	1 AOP 482: Deposition of energy leading to occurrence of bone loss
702	698: Altered, Action Potential	699: Increased, cardiac arrthymia	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
1310	1243: Altered, Ca2+-calmodulin activated signal transduction	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	4 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
977	317: Altered, Cardiovascular development/function	358: Increase, Pericardial edema	Nov 29, 2016	Jun 9, 2017	None
1352	317: Altered, Cardiovascular development/function	350: Increase, Mortality	Feb 9, 2017	Feb 9, 2017	None
1567	317: Altered, Cardiovascular development/function	947: Increase, Early Life Stage Mortality	Jun 9, 2017	Mar 23, 2018	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3189	2115: Cholesterol metabolism	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3196	2115: Cholesterol metabolism	2221: LXR activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
723	723: Altered, Chromosome number	728: Increase, Aneuploid offspring	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
1298	1239: Altered, Gene Expression	1240: Altered, Protein Production	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1807	1239: Altered, Gene Expression	1560: Altered differentiation	Dec 20, 2018	Dec 20, 2018	1 AOP 275: Histone deacetylase inhibition leads to neural tube defects
2468	1930: Altered, inner ear development	1008: Reduced, Hearing	Aug 23, 2021	Aug 23, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
738	752: Altered, Meiotic chromosome dynamics	723: Altered, Chromosome number	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2383	752: Altered, Meiotic chromosome dynamics	1775: Increase, Oocyte apoptosis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2384	752: Altered, Meiotic chromosome dynamics	1798: Decreased spermatogenesis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2391	752: Altered, Meiotic chromosome dynamics	1550: Ionizing Energy	May 12, 2021	May 12, 2021	None
2554	752: Altered, Meiotic chromosome dynamics	1965: Increase, Pollen abnormal	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
203	186: Altered, Neuroanatomy	192: Altered, Neurophysiology	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
384	192: Altered, Neurophysiology	402: Cognitive Function, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2789	2067: Altered, Nitric Oxide Levels	2068: Increase, Endothelial Dysfunction	Oct 20, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
1918	1640: Altered, Photoreceptor patterning	1643: Altered, Visual function	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning

Key Event Relationships (KERs)

All KERs