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Showing 926 to 950 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2739	2047: Delay, Ovarian maturation	2048: Increase, Body volume of female adults	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2740	2047: Delay, Ovarian maturation	2049: Increase, sex ratio (F/M)	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
1182	1140: Delayed, Sexual maturity	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
3261	2247: Demyelination, increased	2248: Delayed neuropathy, increased	Sep 6, 2024	Sep 26, 2024	2 AOPs 535: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 536: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
1181	1143: Depletion, energy reserves	1140: Delayed, Sexual maturity	Nov 29, 2016	Dec 3, 2016	None
1185	1143: Depletion, energy reserves	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
2878	130: Depletion, GSH	1115: Increased, Reactive oxygen species	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
3133	1482: Depletion, mtDNA	177: Mitochondrial dysfunction	Feb 28, 2024	Feb 28, 2024	1 AOP 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1977	1686: Energy Deposition	1635: Increase, DNA strand breaks	Aug 26, 2019	Mar 8, 2024	6 AOPs 272: Deposition of energy leading to lung cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 470: Deposition of energy leads to vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
1981	1686: Energy Deposition	185: Increase, Mutations	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1982	1686: Energy Deposition	1636: Increase, Chromosomal aberrations	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1983	1686: Energy Deposition	1556: Increase, lung cancer	Aug 29, 2019	Jul 5, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2548	1686: Energy Deposition	1115: Increased, Reactive oxygen species	Jan 21, 2022	Jan 21, 2022	2 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2552	1686: Energy Deposition	1194: Increase, DNA Damage	Jan 21, 2022	Jan 21, 2022	4 AOPs 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2557	1686: Energy Deposition	257: Increase, ROS production	Feb 4, 2022	Feb 4, 2022	2 AOPs 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2604	1686: Energy Deposition	1978: Microcephaly	Mar 17, 2022	Mar 17, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2616	1686: Energy Deposition	1632: Increase in RONS	Mar 28, 2022	Mar 28, 2022	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2769	1686: Energy Deposition	1392: Oxidative Stress	Sep 28, 2022	Mar 8, 2024	4 AOPs 470: Deposition of energy leads to vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts
2770	1686: Energy Deposition	2003: Vascular remodeling	Sep 28, 2022	Sep 28, 2022	None
2779	1686: Energy Deposition	2067: Altered, Nitric Oxide Levels	Sep 28, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
2780	1686: Energy Deposition	2068: Increase, Endothelial Dysfunction	Sep 28, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
2785	1686: Energy Deposition	2069: Occurrence, Vascular Remodeling	Oct 17, 2022	Mar 21, 2023	1 AOP 470: Deposition of energy leads to vascular remodeling
2809	1686: Energy Deposition	2081: Modified Proteins	Dec 16, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2813	1686: Energy Deposition	1634: Increase, Oxidative DNA damage	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
2814	1686: Energy Deposition	870: Increase, Cell Proliferation	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts

Key Event Relationships (KERs)

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