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Showing 551 to 575 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

550	491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
2290	1845: Coagulation	1846: Thrombosis and DIC	Mar 25, 2021	Feb 5, 2023	1 AOP 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
2313	1845: Coagulation	1392: Oxidative Stress	Apr 8, 2021	Apr 8, 2021	None
2360	1845: Coagulation	1869: Diminished Protective Response to ROS	Apr 20, 2021	Oct 17, 2023	1 AOP 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
2801	2075: Hemocyanin Bohr effect decrease	2077: behavioral change leading to possible reduced feeding opportunity	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1359	1275: Collagen Deposition	1276: Lung fibrosis	Feb 15, 2017	Feb 15, 2017	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1628	1275: Collagen Deposition	68: Accumulation, Collagen	Jul 26, 2017	Jul 26, 2017	None
1804	1558: Reduced collagen production	1559: Smaller and morphologically distorted facial cartilage structures	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
2877	2131: Conjugation, GSH	130: Depletion, GSH	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
2276	1835: Cortisol and 11β-(OH) testosterone decreased	1836: Decreased plasma Cortisol level	Feb 9, 2021	Feb 9, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
2277	1835: Cortisol and 11β-(OH) testosterone decreased	1756: Decreased, 11KT	Feb 9, 2021	Feb 9, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
376	396: Covalent Binding, Protein	397: Response, Keratinocytes	Nov 29, 2016	Dec 3, 2016	None
377	396: Covalent Binding, Protein	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
833	396: Covalent Binding, Protein	826: Activation, Keratinocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 40: Covalent Protein binding leading to Skin Sensitisation
2202	396: Covalent Binding, Protein	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways	Nov 5, 2020	Feb 11, 2021	None
2649	396: Covalent Binding, Protein	1496: Increased proinflammatory mediators	Apr 28, 2022	Sep 8, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
2650	396: Covalent Binding, Protein	313: Increase, Allergic Respiratory Hypersensitivity Response	Apr 28, 2022	Aug 1, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
1726	1508: CYP2E1 Activation	1510: Oxidative Stress in Brain	Apr 4, 2018	Apr 5, 2018	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3230	2228: CYP450 Upregulation	1392: Oxidative Stress	Jun 4, 2024	Jun 4, 2024	1 AOP 532: CYP450 upregulation leads to Chronic kidney disease
1493	1386: CYP7B activity, inhibition	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1494	1386: CYP7B activity, inhibition	1389: Locomotor activity, decreased	May 2, 2017	May 17, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
2440	1906: CFTR Function, Decreased	1907: ASL Height, Decreased	Jul 19, 2021	Sep 7, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
839	829: Damage, Lipid bilayer	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
840	829: Damage, Lipid bilayer	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
841	829: Damage, Lipid bilayer	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity

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