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Showing 2076 to 2100 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1037	1009: Inhibition, Deiodinase 1	1003: Decreased, Triiodothyronine (T3)	Nov 29, 2016	Oct 10, 2022	2 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
1044	1009: Inhibition, Deiodinase 1	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 10, 2022	1 AOP 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1045	1009: Inhibition, Deiodinase 1	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Mar 8, 2019	None
1198	1009: Inhibition, Deiodinase 1	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
1026	1002: Inhibition, Deiodinase 2	1003: Decreased, Triiodothyronine (T3)	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
1042	1002: Inhibition, Deiodinase 2	1004: Reduced, Posterior swim bladder inflation	Nov 29, 2016	Oct 7, 2022	1 AOP 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1043	1002: Inhibition, Deiodinase 2	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Mar 8, 2019	None
1199	1002: Inhibition, Deiodinase 2	1116: Decreased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
1200	1153: Inhibition, Deiodinase 3	1154: Increased, Triiodothyronine (T3) in tissues	Nov 29, 2016	Dec 3, 2016	1 AOP 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1203	1156: Inhibition, Dual oxidase	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
3121	2207: inhibition, EKR1/2 signaling pathway	2208: Aberrant, synaptic formation and plasticity	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
597	593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	585: Decreased, Sodium conductance 1	Nov 29, 2016	Dec 3, 2016	1 AOP 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
1692	1490: Inhibition of fatty acid beta oxidation	1305: Increase, cytosolic fatty acid	Nov 13, 2017	Nov 13, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1056	1016: Inhibition, Feeding	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
3087	1016: Inhibition, Feeding	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2080	1761: Inhibition, Fin regeneration	1005: Reduced, Swimming performance	Apr 21, 2020	Jul 10, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
519	471: Inhibition, FoxA2	472: Down Regulation, CPT1A	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
523	471: Inhibition, FoxA2	474: Down Regulation, HMGCS2	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
804	804: Inhibition, HMG-CoA reductase	805: Decreased, mevalonate	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
1827	1574: Inhibition, IKK complex	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
159	147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	270: Induction, Sustained Hepatotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
1197	1152: Inhibition, Iodotyrosine deiodinase (IYD)	425: Thyroidal Iodide, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
2476	1152: Inhibition, Iodotyrosine deiodinase (IYD)	281: T4 in serum, Decreased	Sep 9, 2021	Sep 9, 2021	1 AOP 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
1413	1307: Inhibition, LXR	468: Inhibition, PPAR alpha	Apr 12, 2017	Apr 12, 2017	None
2565	105: Inhibition, ETC complexes of the respiratory chain	1969: Increase, Oxidative Stress	Feb 8, 2022	Mar 7, 2022	1 AOP 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity

Key Event Relationships (KERs)

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