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Showing 776 to 800 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3125	2203: Decreased proliferation of cortical NPCs	2201: RAR agonism	Feb 2, 2024	Feb 2, 2024	None
3126	2203: Decreased proliferation of cortical NPCs	2210: Reduced cortical thickness	Feb 2, 2024	Feb 2, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1766	1538: Protection against oxidative stress, decreased	1392: Oxidative Stress	Sep 13, 2018	Feb 7, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1812	1563: Decreased proximal tubular vectorial transport	1564: Chemical induced Fanconi syndrome	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
1916	1641: retinoic acid	1642: plasma retionic acid	May 22, 2019	May 22, 2019	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1615	1451: decreased reward	1452: decreased DNA methylation of tyrosine hydroxylase	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1616	1451: decreased reward	1453: decreased methylation of dopamine transporter promoter	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1617	1451: decreased reward	1450: decreased dopamine	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
2611	1981: Decrease,SIRT1(sirtuin 1) levels	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1650	520: Decreased sperm quantity or quality in the adult, Decreased fertility	406: impaired, Fertility	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
2161	1798: Decreased spermatogenesis	406: impaired, Fertility	Jul 13, 2020	Jul 13, 2020	2 AOPs 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2388	1798: Decreased spermatogenesis	1696: Decrease of egg production and cummulative fecundity	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2620	1798: Decreased spermatogenesis	328: Decrease, Fecundity	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2623	1798: Decreased spermatogenesis	1863: Decrease, Reproduction	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2624	1798: Decreased spermatogenesis	360: Decrease, Population growth rate	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
3168	647: Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes	1690: Decrease, testosterone levels	Mar 20, 2024	Apr 5, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
3171	647: Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes	1613: Decrease, DHT level	Mar 20, 2024	Apr 11, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
2076	1756: Decreased, 11KT	1758: Impaired, Spermatogenesis	Apr 16, 2020	Apr 19, 2021	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2165	1756: Decreased, 11KT	330: Decrease, Fertility	Jul 21, 2020	Jul 21, 2020	None
2166	1756: Decreased, 11KT	1798: Decreased spermatogenesis	Jul 21, 2020	Jul 21, 2020	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
9	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	179: Decreased, Mitochondrial fatty acid beta-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
1530	1401: Decreased, 5-HT3	1344: Increased, seizure	Jun 1, 2017	Jun 1, 2017	1 AOP 223: Serotonin transporter activation to seizure
2477	1881: Decreased, atRA concentration	1882: Oocyte meiosis, disrupted	Sep 10, 2021	Feb 27, 2022	1 AOP 398: Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
2561	1881: Decreased, atRA concentration	1682: Disruption, Progenitor cells of second heart field	Feb 8, 2022	Feb 15, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
2630	1987: Decreased , Androgen and Progestin	1988: Decreased, Maturation Inducing Steroids Surge by Granulosa cells	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction

Key Event Relationships (KERs)

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