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Showing 2351 to 2375 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1565	1427: Opening of GIRK channels	763: hyperpolarisation, neuron	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
3040	2187: Opening VGCCs	389: Increased, Intracellular Calcium overload	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
606	601: Overactivation, muscle contraction	602: Increased, Ataxia, paralysis, or hyperactivity	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality
605	600: Overactivation, Neuronotransmitter release	601: Overactivation, muscle contraction	Nov 29, 2016	Dec 3, 2016	1 AOP 96: Axonal sodium channel modulation leading to acute mortality
361	388: Overactivation, NMDARs	389: Increased, Intracellular Calcium overload	Nov 29, 2016	Sep 10, 2023	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2781	388: Overactivation, NMDARs	1788: Status epilepticus	Oct 12, 2022	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
2806	388: Overactivation, NMDARs	2078: Loss of drebrin	Dec 11, 2022	Dec 11, 2022	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3038	388: Overactivation, NMDARs	1527: Increase, Cell membrane depolarization	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3068	388: Overactivation, NMDARs	12: AchE Inhibition	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3069	388: Overactivation, NMDARs	618: Decreased, Neuronal network function in adult brain	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
3071	388: Overactivation, NMDARs	188: Neuroinflammation	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
2404	1886: Overexpression of rasl11b	1821: Decrease, Cell proliferation	May 28, 2021	Dec 12, 2021	1 AOP 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
661	664: Overwhelmed, Mitochondrial DNA repair mechanisms	570: Accumulation, Damaged mitochondrial DNA	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1852	1596: Oxidation of DNA	1599: Inflammatory events	Feb 4, 2019	Feb 4, 2019	None
1850	1594: Oxidation of membrane lipids	1599: Inflammatory events	Feb 4, 2019	Jul 9, 2019	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
954	926: Oxidation, Glutathione	927: S-Glutathionylation, eNOS	Nov 29, 2016	Sep 28, 2017	None
2459	926: Oxidation, Glutathione	1115: Increased, Reactive oxygen species	Aug 5, 2021	Aug 5, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
864	844: Oxidation, Uroporphyrinogen	846: Accumulation, Highly carboxylated porphyrins	Nov 29, 2016	Nov 29, 2016	None
865	844: Oxidation, Uroporphyrinogen	845: Inhibition, UROD	Nov 29, 2016	May 30, 2018	1 AOP 131: Aryl hydrocarbon receptor activation leading to uroporphyria
1851	1595: Oxidation/denatuation of membrane proteins	1599: Inflammatory events	Feb 4, 2019	Jul 9, 2019	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1513	1392: Oxidative Stress	1393: Hepatocytotoxicity	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1516	1392: Oxidative Stress	1395: Liver Cancer	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1685	1392: Oxidative Stress	1488: Glutamate dyshomeostasis	Nov 9, 2017	Feb 6, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1690	1392: Oxidative Stress	55: Cell injury/death	Nov 9, 2017	Feb 7, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
2008	1392: Oxidative Stress	1645: Wnt ligand stimulation	Dec 3, 2019	Dec 3, 2019	None

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