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All KERs

Showing 1076 to 1100 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

548	373: Formation, Pro-mutagenic DNA Adducts	493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
551	373: Formation, Pro-mutagenic DNA Adducts	491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
1062	976: Formation, The binding of FK506 with FKBP12	980: Inhibition, Calcineurin Activity	Nov 29, 2016	Dec 3, 2016	None
2437	1903: foxi1 expression, increased	1904: six1b expression, increased	Jul 14, 2021	Oct 28, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
2447	1911: FOXJ1 Protein, Decreased	1912: Motile Cilia Number/Length, Decreased	Jul 23, 2021	Aug 2, 2021	1 AOP 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1925	1646: Frizzled activation	1647: GSK3beta inactivation	May 29, 2019	May 29, 2019	None
1962	1668: Frustrated phagocytosis	87: Release, Cytokine	Jul 3, 2019	Aug 13, 2019	1 AOP 303: Frustrated phagocytosis-induced lung cancer
2415	1668: Frustrated phagocytosis	1496: Increased proinflammatory mediators	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2416	1668: Frustrated phagocytosis	1115: Increased, Reactive oxygen species	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
1733	1513: General Apoptosis	1514: Neurodegeneration	Apr 4, 2018	Apr 5, 2018	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
2977	1513: General Apoptosis	885: Increase, Cancer	Jul 31, 2023	Oct 19, 2023	2 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1289	1236: Generation of novel epitopes , Antigen presentation	1237: Sensitization, Immune system	Nov 29, 2016	Dec 3, 2016	None
684	682: Generation, Amplified excitatory postsynaptic potential (EPSP)	616: Occurrence, A paroxysmal depolarizing shift	Nov 29, 2016	May 15, 2018	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
2418	1896: Genomic instability	870: Increase, Cell Proliferation	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2973	1896: Genomic instability	2154: endometrioid adenocarcinoma Type I	Jul 27, 2023	Jul 27, 2023	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1645	494: GR Agonist, Activation	496: Decreased Leydig Cells	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
1646	494: GR Agonist, Activation	495: Repressed expression of steroidogenic enzymes	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
1686	1488: Glutamate dyshomeostasis	55: Cell injury/death	Nov 9, 2017	Feb 6, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1691	1488: Glutamate dyshomeostasis	386: Neuronal network function, Decreased	Nov 9, 2017	Nov 9, 2017	None
1378	1290: Glutathione homeostasis	1291: Hepatotoxicity	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1374	1287: Glutathione synthesis	1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
3142	1800: Reduced granulosa cell proliferation	405: irregularities, ovarian cycle	Mar 7, 2024	Mar 7, 2024	1 AOP 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
1926	1647: GSK3beta inactivation	1648: β-catenin activation	May 29, 2019	May 29, 2019	None
2485	1647: GSK3beta inactivation	1902: Repression of Gbx2 expression	Oct 3, 2021	Dec 12, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
2533	1954: Gut dysbiosis	1931: Disruption of the intestinal barrier	Dec 2, 2021	Dec 2, 2021	None

Key Event Relationships (KERs)

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