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Showing 1701 to 1725 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2146	1790: Increased, Differentiation to Testis	1791: Increased, Male Biased Sex Ratio	Jun 15, 2020	Jan 3, 2023	2 AOPs 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 376: Androgen receptor agonism leading to male-biased sex ratio
3250	2239: Increased, disregulation of smooth muscle cells	2237: Increased, Endothelin protein	Jun 19, 2024	Jun 19, 2024	None
1966	1669: Increased, DNA damage and mutation	870: Increase, Cell Proliferation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
2417	1669: Increased, DNA damage and mutation	1896: Genomic instability	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2608	1669: Increased, DNA damage and mutation	155: Inadequate DNA repair	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
2728	1669: Increased, DNA damage and mutation	1554: Increase chromosomal aberrations	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1366	1281: Increased, DNA Damage-Repair	1262: Apoptosis	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1252	1192: Increased, Ductal Hyperplasia	1193: N/A, Breast Cancer	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
3256	2242: Increased, edn1 gene expression	2237: Increased, Endothelin protein	Jun 20, 2024	Jun 20, 2024	1 AOP 534: Activation of Protein kinase C leads to Kidney Failure
3251	2237: Increased, Endothelin protein	2231: Increased, activation of RAAS	Jun 19, 2024	Jun 19, 2024	None
3253	2237: Increased, Endothelin protein	2230: Increased, afferent artery vasoconstriction	Jun 19, 2024	Jun 21, 2024	1 AOP 534: Activation of Protein kinase C leads to Kidney Failure
1157	1110: Increased, Energetic demands and therefore metabolic stress	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 183: Nosema infection increases energetic demands leading to colony loss/failure
3082	1363: Increased, epilepsy	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Various neuronal effects induced by elavl3, sox10, and mbp
1250	1187: Increased, ER binding to DNA (classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1296	1187: Increased, ER binding to DNA (classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1251	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1297	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
3115	2205: Increased, essential element imbalance	1115: Increased, Reactive oxygen species	Jan 24, 2024	Apr 11, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress
734	748: Increased, Estrogen receptor (ER) activity	749: Decreased, Progesterone from corpus luteum	Nov 29, 2016	Dec 3, 2016	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
2737	748: Increased, Estrogen receptor (ER) activity	2046: Increase, Vitellogenin mRNA	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2583	1973: Increased, estrogens	1076: Increased, circulating estrogen levels	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3104	2199: Increased, Expression of LXR activated genes	89: Synthesis, De Novo Fatty Acid (FA)	Dec 7, 2023	Mar 29, 2024	1 AOP 518: Liver X Receptor (LXR) activation leads to liver steatosis
1708	1501: Increased extracellular matrix deposition	1458: Pulmonary fibrosis	Jan 16, 2018	Dec 6, 2021	None
2325	1501: Increased extracellular matrix deposition	344: N/A, Liver fibrosis	Apr 10, 2021	Apr 10, 2021	2 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 494: AhR activation leading to liver fibrosis
1521	1320: Increased, extracellular serotonin	1347: Decreased, extracellular serotonin	May 30, 2017	May 30, 2017	None

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