AOP-Wiki

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All Key Events

Showing 1051 to 1075 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1485	Binding of substrate, endocytotic receptor Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	None
1486	Binding of substrate, endocytic receptor Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1487	Binding, Thiol/seleno-proteins involved in protection against oxidative stress Short Name	0	Molecular	Nov 9, 2017	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1488	Glutamate dyshomeostasis Short Name Glutamate dyshomeostasis	0	Cellular	Nov 9, 2017	Jul 15, 2022	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1489	N/A, Steatohepatisis Short Name steatohepatitis	0	Organ	Nov 13, 2017	Nov 27, 2017	2 AOPs 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1490	Inhibition, Fatty Acid Beta Oxidation Short Name Inhibition of fatty acid beta oxidation	0	Molecular	Nov 13, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1491	Increased, Oncotic Necrosis Short Name increased, oncotic necrosis	0	Tissue	Nov 14, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1492	Tissue resident cell activation Short Name Tissue resident cell activation	1	Cellular	Nov 28, 2017	Mar 22, 2023	5 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 483: Deposition of Energy Leading to Learning and Memory Impairment
1493	Increased Pro-inflammatory mediators Short Name Increased pro-inflammatory mediators	1	Tissue	Nov 28, 2017	Mar 21, 2023	8 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 470: Deposition of energy leads to vascular remodeling
1494	Leukocyte recruitment/activation Short Name Leukocyte recruitment/activation	1	Cellular	Nov 28, 2017	Dec 1, 2017	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 494: AhR activation leading to liver fibrosis
1495	Substance interaction with the lung resident cell membrane components Short Name Interaction with the lung cell membrane	3	Molecular	Jan 2, 2018	May 17, 2023	3 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1496	Increased, secretion of proinflammatory mediators Short Name Increased proinflammatory mediators	4	Cellular	Jan 2, 2018	May 17, 2023	11 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response 319: Binding to ACE2 leading to lung fibrosis 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1497	Increased, recruitment of inflammatory cells Short Name Recruitment of inflammatory cells	2	Tissue	Jan 3, 2018	May 12, 2023	9 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 303: Frustrated phagocytosis-induced lung cancer 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 533: C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
1498	Loss of alveolar capillary membrane integrity Short Name	0	Tissue	Jan 3, 2018	May 17, 2023	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 302: Lung surfactant function inhibition leading to decreased lung function
1499	Increased, activation of T (T) helper (h) type 2 cells Short Name Activation of Th2 cells	0	Tissue	Jan 3, 2018	May 12, 2023	173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1500	Increased, fibroblast proliferation and myofibroblast differentiation Short Name	0	Tissue	Jan 5, 2018	May 17, 2023	173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
1501	Increased, extracellular matrix deposition Short Name	0	Tissue	Jan 5, 2018	Jan 25, 2022	4 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 494: AhR activation leading to liver fibrosis
1502	Histone deacetylase inhibition Short Name Histone deacetylase inhibition	1	Molecular	Jan 21, 2018	Jul 14, 2022	4 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 274: Histone deacetylase inhibition leads to impeded craniofacial development 275: Histone deacetylase inhibition leads to neural tube defects 449: Ceramide synthase inhibition leading to neural tube defects
1503	Histone acetylation, increase Short Name Histone acetylation, increase	1	Cellular	Jan 21, 2018	Jul 28, 2021	3 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 275: Histone deacetylase inhibition leads to neural tube defects 533: C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
1504	p21 (CDKN1A) expression, increase Short Name p21 (CDKN1A) expression, increase	1	Cellular	Jan 21, 2018	Nov 26, 2018	None
1505	Cell cycle, disrupted Short Name Cell cycle, disrupted	1	Cellular	Jan 21, 2018	Jun 30, 2021	3 AOPs 212: Histone deacetylase inhibition leading to testicular atrophy 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1506	Testicular atrophy Short Name Testicular atrophy	1	Organ	Jan 21, 2018	Jul 1, 2021	212: Histone deacetylase inhibition leading to testicular atrophy
1507	Activation of PPARγ Short Name Activation of PPARγ	0	Molecular	Mar 18, 2018	Mar 18, 2018	None
1508	CYP2E1 Activation Short Name CYP2E1 Activation	0	Molecular	Mar 26, 2018	Apr 9, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
1509	Protein Adduct Formation Short Name Protein Adduct Formation	0	Molecular	Mar 26, 2018	Mar 26, 2018	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration