AOP-Wiki

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All KERs

Showing 526 to 550 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1195	1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei	1150: Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp	Nov 29, 2016	Dec 3, 2016	None
1712	1505: Cell cycle, disrupted	1262: Apoptosis	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
2791	1505: Cell cycle, disrupted	752: Altered, Meiotic chromosome dynamics	Oct 25, 2022	Oct 25, 2022	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
67	55: Cell injury/death	134: Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells)	Nov 29, 2016	Nov 29, 2016	None
68	55: Cell injury/death	265: Activation, Stellate cells	Nov 29, 2016	Nov 29, 2016	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
924	55: Cell injury/death	87: Release, Cytokine	Nov 29, 2016	Nov 9, 2018	None
1688	55: Cell injury/death	386: Neuronal network function, Decreased	Nov 9, 2017	Feb 5, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1718	55: Cell injury/death	1492: Tissue resident cell activation	Feb 1, 2018	Aug 2, 2018	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis
1776	55: Cell injury/death	1493: Increased pro-inflammatory mediators	Nov 12, 2018	Nov 12, 2018	1 AOP 144: Endocytic lysosomal uptake leading to liver fibrosis
1830	55: Cell injury/death	1548: Necrotic Tissue	Jan 7, 2019	Mar 7, 2019	2 AOPs 278: IKK complex inhibition leading to liver injury 273: Mitochondrial complex inhibition leading to liver injury
1831	55: Cell injury/death	1576: Activation, Tissue resident cells (Kuppfer cells)	Jan 7, 2019	Jan 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1863	55: Cell injury/death	1514: Neurodegeneration	Feb 19, 2019	Feb 19, 2019	None
2767	55: Cell injury/death	1521: Decrease, Growth	Sep 27, 2022	Sep 27, 2022	4 AOPs 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
2875	55: Cell injury/death	758: Hippocampal Physiology, Altered	Apr 5, 2023	Apr 5, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2890	55: Cell injury/death	1494: Leukocyte recruitment/activation	Apr 13, 2023	Apr 13, 2023	1 AOP 494: AhR activation leading to liver fibrosis
3197	55: Cell injury/death	1931: Disruption of the intestinal barrier	Apr 17, 2024	Apr 17, 2024	1 AOP 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
3198	55: Cell injury/death	177: Mitochondrial dysfunction	Apr 17, 2024	Apr 17, 2024	None
995	853: Changes/Inhibition, Cellular Homeostasis and Apoptosis	139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects	Nov 29, 2016	Dec 2, 2016	1 AOP 41: Sustained AhR Activation leading to Rodent Liver Tumours
1613	1454: chronic high fat diet	1450: decreased dopamine	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
2069	1753: Chronic ROS	1754: Porcupine-induced Wnt secretion and Wnt signaling activation	Mar 23, 2020	May 13, 2021	1 AOP 298: Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
1314	1251: Chronic, Mucus hypersecretion	1250: Decreased lung function	Nov 29, 2016	Aug 30, 2021	None
2442	1908: CBF, Decreased	1909: MCC, Decreased	Jul 19, 2021	Mar 24, 2023	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1

Key Event Relationships (KERs)

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