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All Key Events

Showing 126 to 150 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

280	Thyroxine (T4) in neuronal tissue, Decreased Short Name T4 in neuronal tissue, Decreased	1	Organ	Nov 29, 2016	Apr 4, 2019	8 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
281	Thyroxine (T4) in serum, Decreased Short Name T4 in serum, Decreased	1	Tissue	Nov 29, 2016	Oct 10, 2022	25 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 128: Kidney dysfunction by decreased thyroid hormone 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
285	Reduction, Vitellogenin synthesis in liver Short Name	2	Tissue	Nov 29, 2016	May 27, 2021	6 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
286	Altered, Transcription of genes by the androgen receptor Short Name	1	Tissue	Nov 29, 2016	Apr 5, 2024	6 AOPs 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 495: Androgen receptor activation leading to prostate cancer
288	Activation of specific nuclear receptors, Transcriptional change Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
289	Decrease, Translocator protein (TSPO) Short Name Decrease, Translocator protein (TSPO)	1	Cellular	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
291	Accumulation, Triglyceride Short Name Accumulation, Triglyceride	1	Cellular	Nov 29, 2016	Mar 26, 2024	6 AOPs 34: LXR activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
294	N/A, Unknown Short Name N/A, Unknown	0	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 33: Kidney toxicity induced by activation of 5HT2C 1: Uncharacterized liver damage leading to hepatocellular carcinoma
295	Induction, Upregulation of glucuronyltransferase activity Short Name	2	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
298	Insufficiency, Vascular Short Name Insufficiency, Vascular	2	Molecular	Nov 29, 2016	Jul 20, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
301	Binding, VEGF-A Short Name Binding, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
302	Production, VEGF-A Short Name Production, VEGF-A	0		Nov 29, 2016	Nov 29, 2016	None
304	Decreased, VegfR2 Short Name Decreased, VegfR2	0		Nov 29, 2016	Nov 29, 2016	None
305	Inhibition, VegfR2 Short Name Inhibition, VegfR2	2	Molecular	Nov 29, 2016	Jan 17, 2022	43: Disruption of VEGFR Signaling Leading to Developmental Defects
307	Increase, Vitellogenin synthesis in liver Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	29: Estrogen receptor agonism leading to reproductive dysfunction
309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Short Name	3	Cellular	Nov 29, 2016	Sep 16, 2017	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
310	Alteration, Wnt pathway Short Name Alteration, Wnt pathway	1	Cellular	Nov 29, 2016	Sep 16, 2017	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
312	N/A, Allergic contact dermatitis on challenge Short Name	0	Individual	Nov 29, 2016	Nov 29, 2016	None
313	Increase, Allergic Respiratory Hypersensitivity Response Short Name	1	Organ	Nov 29, 2016	Feb 7, 2023	39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
315	Decreased, Body length Short Name Decreased, Body length	0		Nov 29, 2016	Nov 29, 2016	None
317	Altered, Cardiovascular development/function Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
319	Loss, Cochlear function Short Name Loss, Cochlear function	1	Organ	Nov 29, 2016	Sep 16, 2017	8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
320	Increase, Curved body axis Short Name Increase, Curved body axis	0		Nov 29, 2016	Nov 29, 2016	None
321	N/A, Cyanosis occurs Short Name N/A, Cyanosis occurs	1	Individual	Nov 29, 2016	Dec 3, 2016	31: Oxidation of iron in hemoglobin leading to hematotoxicity
323	Increased, Disease susceptibility Short Name Increased, Disease susceptibility	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility